Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8399120 | Mitochondrion | 2016 | 29 Pages |
Abstract
Modifications of cardiolipin (CL) levels or compositions are associated with changes in mitochondrial function in a wide range of pathologies. We have made the discovery that acetaminophen remodels CL fatty acids composition from tetralinoleoyl to linoleoyltrioleoyl-CL, a remodeling that is associated with decreased mitochondrial respiration. Our data show that CL remodeling causes a shift in electron entry from complex II to the β-oxidation electron transfer flavoprotein quinone oxidoreductase (ETF/QOR) pathway. These data demonstrate that electron entry in the respiratory chain is regulated by CL fatty acid composition and provide proof-of-concept that pharmacological intervention can be used to modify CL composition.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biophysics
Authors
Aurelia Vergeade, Clinton C. Bertram, Alfiya T. Bikineyeva, William E. Zackert, Sandra S. Zinkel, James M. May, Sergey I. Dikalov, L. Jackson II, Olivier Boutaud,