Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8399238 | Mitochondrion | 2015 | 6 Pages |
Abstract
Opening of the mitochondrial permeability transition (MPT) pore mediates the increase in the unselective permeability to ions and small molecules across the inner mitochondrial membrane. MPT results from the opening of channels of unknown identity in mitochondria from plants, animals and yeast. However, the effectors and conditions required for MPT to occur in different species are remarkably disparate. Here we critically review previous and recent findings concerning the mitochondrial unselective channel of the yeast Saccharomyces cerevisiae to determine if it can be considered a counterpart of the mammalian MPT pore.
Keywords
MCUCyclophilin DG6PVDACMPTANTPICCypDDUBEGTAdecylubiquinoneMMCROSethylene glycol tetraacetic acidPermeability transition porePermeability transitionmitochondrial permeability transitionCSAtriethanolamineMitochondrial evolutionPhosphate carrierDecavanadateBioenergeticsCyclosporine AMitochondrial calcium uniporterCell deathYeast mitochondriaTEAvoltage-dependent anion channelGlucose 6-phosphateReactive oxygen species
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Authors
Manuel Gutiérrez-Aguilar, Salvador Uribe-Carvajal,