Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8399253 | Mitochondrion | 2014 | 6 Pages |
Abstract
This study of 200 Caucasian women shows that the distribution of the mtDNA macro-haplogroups in patients with diminished ovarian reserve (DOR) differed significantly from that of patients with normal ovarian reserve (NOR) (p = 0.02). The JT macro-haplogroup was significantly under-represented in DOR patients compared with NOR patients (p = 0.006) and compared with the estimated frequency of 18.8% in the general French population (p = 0.0012). Our findings suggest that the risk of a prematurely depleted ovarian reserve would be three times lower for patients carrying the JT macro-haplogroup than for patients with any of the other mtDNA haplogroups (odds ratio: 0.3; 95% CI: 0.13-0.74). If these preliminary results are confirmed in larger independent studies, they should lead to the better management of infertility.
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Authors
P. May-Panloup, V. Desquiret, C. Morinière, V. Ferré-L'Hôtellier, S. Lemerle, L. Boucret, S. Lehais, J.M. Chao de la Barca, P. Descamps, V. Procaccio, P. Reynier,