Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8400848 | Progress in Biophysics and Molecular Biology | 2016 | 17 Pages |
Abstract
The Dynamic Clamp approach, applied to the If study in cardiomyocytes for the first time and rate-adapted to manage intercellular variability, indicated that: i) the quantitative description of the If current in the Severi-DiFrancesco model accurately reproduces the effects of the real current on rabbit sinoatrial cell pacemaking rate and ii) a significant portion (50-60%) of the physiological autonomic rate modulation is due to the shift of the If activation curve.
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Authors
E. Ravagli, A. Bucchi, C. Bartolucci, M. Paina, M. Baruscotti, D. DiFrancesco, S. Severi,