Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8401146 | Progress in Biophysics and Molecular Biology | 2014 | 14 Pages |
Abstract
This paper reviews the development and application of paired muscle preparations, called duplex, for the investigation of mechanisms and consequences of intra-myocardial electro-mechanical heterogeneity. We illustrate the utility of the underlying combined experimental and computational approach for conceptual development and integration of basic science insight with clinically relevant settings, using previously published and new data. Directions for further study are identified.
Keywords
TNCLmaxAPDEPICrt[Ca2+]iendoMechano-electric feedbackCardiac tissueleft ventricleExcitation-contraction couplingCardiac resynchronization therapySarcoplasmic reticulumNormal cellintracellular free Ca2+ concentrationAction potential durationaction potentialMembrane potentialDispersion of repolarizationone-dimensional
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Authors
O. Solovyova, L.B. Katsnelson, P.V. Konovalov, A.G. Kursanov, N.A. Vikulova, P. Kohl, V.S. Markhasin,