Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8401197 | Progress in Biophysics and Molecular Biology | 2014 | 13 Pages |
Abstract
We subsequently performed high-resolution diffusion spectrum imaging (DSI) and 3D whole heart fibre tracking in fixed ex vivo rat hearts in slack state and contracture. As a model-free method, DSI augmented the measurements of water diffusion by also informing on multiple intra-voxel diffusion orientations and non-Gaussian diffusion. This enabled us to identify the transition from right- to left-handed fibres from the subendocardium to the subepicardium, as well as voxels in apical regions that were traversed by multiple fibres. We observed that both the mean generalised fractional anisotropy and mean kurtosis were lower in hearts in contracture compared to the slack state, by 23% and 9.3%, respectively. While its heavy acquisition burden currently limits the application of DSI in vivo, ongoing work in acceleration techniques may enable its use in live animals and patients. This would provide access to the as yet unexplored dimension of non-Gaussian diffusion that could serve as a highly sensitive marker of cardiac micro-structural integrity.
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Authors
Maelene Lohezic, Irvin Teh, Christian Bollensdorff, Rémi Peyronnet, Patrick W. Hales, Vicente Grau, Peter Kohl, Jürgen E. Schneider,