Stem cells and heart disease - Brake or accelerator?

Article ID	Journal	Published Year	Pages	File Type
8402419	Advanced Drug Delivery Reviews	2017	80 Pages	PDF

Abstract

SC: stem cell; HSC: hematopoietic stem cell; NR/R: non-responder/responder; MSC: mesenchymal stem cell.255

Keywords

PEI CPC CSC AcLDL HSC ACC MMP CFU CCL2 TGF-β1 IGF EPC NGS CDC EMA AHA mTOR EPO MSC CEC NOS PGE2 GMP TLR IPSC lncRNAs CXCR4 BMSC IDO SCF GSP CXCL12 MNC GCP LVEF mTORC1 SAE HGF C-X-C motif chemokine 12 VEGFR SH2 Src homology region 2 MACE WGCNA LVESV IGFBP GLP CSF-1 GVP C-C Motif Chemokine Ligand 2 IP-10/CXCL10 ATMP RCV t-SNE HLA-G5 Tbx5 Bone marrow-derived stem cell HIF-1 alpha T-reg FDA IgM Acetylated-low density lipoprotein GxP Ang1 IVUS Long non-coding RNAs ROS regulatory T-cells VE-cadherin TNF alpha Myocardial infarction angiopoietin 1 European Medicines agency US Food and Drug Administration erythropoietin MRI American Heart Association immunoglobulin M interferon IFN interleukin indoleamine 2,3-dioxygenase cardiovascular disease Cardiac disease transforming growth factor beta 1 Weighted gene co-expression network analysis Magnetic resonance imaging Tissue repair toll like receptor Good Manufacturing Practice good practice Good Laboratory Practice Next generation sequencing tumor necrosis factor alpha CABG left ventricular end-systolic volume major adverse cardiac events ESC Peripheral blood CVD Circulating endothelial cell Stem cell cardiac stem cell Hematopoietic stem cell mononuclear cell Embryonic stem cell Mesenchymal stem cell Induced pluripotent stem cell cardiosphere-derived cell Endothelial progenitor cell cardiac progenitor cell NK cells Natural killer cells intravascular ultrasound Systems medicine hypoxia-inducible factor 1 alpha colony-stimulating factor 1 Hepatocyte growth factor good clinical practice Serious adverse event Granulocyte-colony stimulating factor Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)Insulin-like growth factor Stem Cell Factor G-CSF Acute lymphoblastic leukemia matrix metalloproteinase Quality management Genome-wide association studies GWAS bone marrow FAIR Nitric oxide nitric oxide synthase ALL colony-forming unit Responder Non-responder Insulin-like growth factor-binding protein Prostaglandin E2 Single nucleotide polymorphism Coronary artery bypass graft SNP vascular endothelial cadherin American College of Cardiology left ventricular ejection fraction quality control Reactive oxygen species vascular endothelial growth factor receptor Machine learning

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Stem cells and heart disease - Brake or accelerator?

Authors

Gustav Steinhoff, Julia Nesteruk, Markus Wolfien, Jana GroÃe, Ulrike Ruch, Praveen Vasudevan, Paula Müller,