Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8406425 | Biosystems | 2018 | 64 Pages |
Abstract
We, furthermore, show that a single variable variant of the Bertalanffy-type model can straightforwardly be extended to a multiclonal competition model. Since competition is crucially based on available shared or clone-specific resources, the metabolism-based approach is an obvious candidate to capture clonal competition. Depending on the specific context, metabolic reprogramming or other oncogene driven changes either lead to a suppression of cancer cells or to an improved competition resulting in outgrowth of tumours. The parametrisation of the Bertalanffy-type growth model allows to account for this observed variety of cancer characteristics. The shape parameter, conceived as a classifier for healthy and oncogenic phenotypes, supplies a link to survival and evolutionary stability concepts discussed in demographic studies, such as opportunistic versus equilibrium strategies.
Related Topics
Physical Sciences and Engineering
Mathematics
Modelling and Simulation
Authors
Hans H. Diebner, Thomas Zerjatke, Max Griehl, Ingo Roeder,