Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8407238 | Biosystems | 2014 | 12 Pages |
Abstract
Synaptic plasticity, an emergent property of synaptic networks, has shown strong correlation to one of the essential functions of the brain, memory formation. Through understanding synaptic plasticity, we hope to discover the modulators and mechanisms that trigger memory formation. In this paper, we first review the well understood modulators and mechanisms underlying N-methyl-d-aspartate receptor dependent synaptic plasticity, a major form of synaptic plasticity in hippocampus, and then comment on the key mathematical modelling approaches available in the literature to understand synaptic plasticity as the integration of the established functionalities of synaptic components.
Keywords
PSDCa2+/CaM-dependent protein kinase IIPP2BS845PIP2AKAPPP1LFSNMDARPKCHFSTARPCaMKIIPDEpKaAMPARcAMPCyclic adenosine monophosphateadenylyl cyclaseMAGUKlong term depressionpostsynaptic densitylong term potentiationLTPSystems biologyCAMmemory formationPhosphodiesteraseLTDA-kinase anchoring proteinprotein phosphatase 1protein kinase AProtein kinase CSynaptic plasticityCalmodulinCalcineurinN-methyl-d-aspartate receptor
Related Topics
Physical Sciences and Engineering
Mathematics
Modelling and Simulation
Authors
Y. He, D. Kulasiri, S. Samarasinghe,