| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8408498 | Computational and Structural Biotechnology Journal | 2017 | 10 Pages |
Abstract
Chinese hamster ovary cells have been in the spotlight for process optimization in recent years, due to being the major, long established cell factory for the production of recombinant proteins. A deep, quantitative understanding of CHO metabolism and mechanisms involved in protein glycosylation has proven to be attainable through the development of high throughput technologies. Here we review the most notable accomplishments in the field of modelling CHO metabolism and protein glycosylation.
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Authors
Sarah N. Galleguillos, David Ruckerbauer, Matthias P. Gerstl, Nicole Borth, Michael Hanscho, Jürgen Zanghellini,