| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8409993 | Drug Discovery Today | 2018 | 7 Pages |
Abstract
Galectin-3 is a pleiotropic protein involved in cell activation, proliferation and migration and plays a pivotal part as an inflammatory mediator in neurodegeneration. Galectin-3 is associated with microglial activation and proliferation after ischemia. Given its putative role as a dynamic fine-tuner of microglia, activation of Galectin-3 provides molecular cues in design of new immunomodulatory strategies for stroke management. This review summarizes recent evidence on the role of Galectin-3 as a mediator of immune responses in damaged brain and mechanisms employed by Galectin-3 to affect microglial function.
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Authors
Reza Rahimian, Louis-Charles Béland, Jasna Kriz,