| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8410644 | Drug Discovery Today | 2013 | 8 Pages |
Abstract
⺠Fragment screening represents a high-resolution chemogenomics approach. ⺠Probing protein-binding sites with fragments results in new molecular insights. ⺠Affinity cliffs and molecular selectivity switches guide hit fragment optimization.
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Authors
Chris de Graaf, Henry F. Vischer, Gerdien E. de Kloe, Albert J. Kooistra, Saskia Nijmeijer, Martien Kuijer, Mark H.P. Verheij, Paul J. England, Jacqueline E. van Muijlwijk-Koezen, Rob Leurs, Iwan J.P. de Esch,