| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8410688 | Drug Discovery Today | 2013 | 8 Pages |
Abstract
⺠We postulate a generic paradigm for AIMID. ⺠Acute autoimmune inflammation causes injury in an organ. ⺠Chronic inflammation is a dysregulated T cell reaction against antigens released from injury. ⺠T cells lacking CD28 (CD28null) have a central role in the response to injury. ⺠CD28null effector memory T cells are a hallmark of immune ageing.
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Authors
Bert A. 't Hart, Paulina Chalan, Gerrit Koopman, Annemieke M.H. Boots,