| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8410993 | Drug Discovery Today: Disease Models | 2017 | 8 Pages |
Abstract
This review presents an overview on the present status of xenogeneic islet cell transplantation. In four sections we present (1) a short introduction on clinical islet transplantation using islets from deceased humans, ending with the rationale for xenogeneic islet transplantation; (2) porcine islet survival and function in diabetic nonhuman primates; (3) features in this animal model that are relevant for clinical development; and (4) limitations and translational value of the model in nonhuman primates.
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Authors
Melanie L. Graham, Henk-Jan Schuurman,