| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8411128 | Drug Discovery Today: Disease Models | 2011 | 6 Pages |
Abstract
Transforming growth factor β (TGFβ) signaling is implicated in cancer progression since its discovery. Although TGFβ plays tumor suppressor roles, the same pathway also provides pro-tumorigenic fates. The pro-tumorigenic action of TGFβ involves processes like epithelial-mesenchymal transition (EMT), tumor microenvironment remodeling, and eventually metastatic dissemination to new sites of tumor growth. Here, we give an updated overview of TGFβ roles in tumor progression and emphasize current evaluations of TGFβ blockade in preventing EMT and metastasis.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biotechnology
Authors
Katia Savary, Aristidis Moustakas,