In vitro models for immunogenicity prediction of therapeutic proteins

Article ID	Journal	Published Year	Pages	File Type
8411633	European Journal of Pharmaceutics and Biopharmaceutics	2018	40 Pages	PDF

Keywords

DCs Ph. Eur.USP nAbs ISRs MDM PBMCs SCID adipose-derived stem/stromal cells ECL FDA EMA APCs ECM ASCs ADAs TLRs Aln antidrug antibodies Neutralizing antibodies Human leukocyte antigen Antigen presenting cells HLA enzyme-linked immunosorbent assays European Medicines agency US Food and Drug Administration Electrochemiluminescence interleukin Subcutaneous injection ELISA Intravenous subcutaneous peripheral blood mononuclear cells Dendritic cells Langerhans cells Monocyte-derived dendritic cells Intramuscular European Pharmacopoeia Extracellular matrix monocyte-derived macrophages major histocompatibility complex MHC In vitro model ICH injection site reactions Therapeutic protein severe combined immunodeficiency International Conference on Harmonisation Toll-like receptors

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In vitro models for immunogenicity prediction of therapeutic proteins

Authors

Floriane Groell, Olivier Jordan, Gerrit Borchard,