Screening therapeutics according to their uptake across the blood-brain barrier: A high throughput method based on immobilized artificial membrane liquid chromatography-diode-array-detection coupled to electrospray-time-of-flight mass spectrometry

Article ID	Journal	Published Year	Pages	File Type
8411903	European Journal of Pharmaceutics and Biopharmaceutics	2018	13 Pages	PDF

Keywords

Octadecylsilyl PBS MLC ESI APC PLS NCE TOF DAD ODS PSA VIF DPBS diode array detector Ammonium acetate Ultraviolet High-throughput QSPR leave-one-out Partial least squares CNS Molecular dynamics Quantitative structure-activity relationship Quantitative structure-property relationship Time-of-Flight BBB central nervous system Mass spectrometry Time-of-flight mass spectrometry Immobilized artificial membrane Pharmacodynamics Pharmacokinetics Variance inflation factor Dulbecco’s phosphate buffered saline Phosphate buffered saline phosphatidylcholine LOO Blood-brain barrier CSF cerebrospinal fluids IAM Electrospray ionization source Polar surface area new chemical entity Molecular weight liquid chromatography micellar liquid chromatography

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biotechnology

Screening therapeutics according to their uptake across the blood-brain barrier: A high throughput method based on immobilized artificial membrane liquid chromatography-diode-array-detection coupled to electrospray-time-of-flight mass spectrometry

Authors

Giacomo Russo, Lucia Grumetto, Roman Szucs, Francesco Barbato, Frederic Lynen,