Impact of fast and conservative freeze-drying on product quality of protein-mannitol-sucrose-glycerol lyophilizates

Article ID	Journal	Published Year	Pages	File Type
8412028	European Journal of Pharmaceutics and Biopharmaceutics	2018	13 Pages	PDF

Keywords

HP-SEC LYSO mAb HPW SUC XRPD BFD AFD MDSC API AUC Monoclonal antibody Glass transition Crystallization Freeze-Drying Eutectic temperature Product temperature Residual Moisture Sucrose Collapse bulking agent Collapse temperature lysozyme Mannitol Man area under the curve Active Pharmaceutical Ingredient Light obscuration Controlled nucleation Hemihydrate Protein stability X-ray powder diffraction Modulated differential scanning calorimetry high performance size exclusion chromatography Gly Glycerol

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biotechnology

Impact of fast and conservative freeze-drying on product quality of protein-mannitol-sucrose-glycerol lyophilizates

Authors

Jacqueline Horn, Julia Schanda, Wolfgang Friess,