Development of a non-toxic and non-denaturing formulation process for encapsulation of SDF-1Î± into PLGA/PEG-PLGA nanoparticles to achieve sustained release

Article ID	Journal	Published Year	Pages	File Type
8412071	European Journal of Pharmaceutics and Biopharmaceutics	2018	13 Pages	PDF

Keywords

CXCR4 FBS LNC NaCl DMEM GBM P188 HCl PBS HPBCD DMI SEC SDF-1α TRIS PLGA NIH3T3 PDI AFM PVA nuclear magnetic resonance BSA DMSO Sustained release bovine serum albumin hydrochloric acid standard deviation Tem Drug loading Encapsulation efficiency Tris(hydroxymethyl)-aminomethane Enzyme-linked immunosorbent assay ELISA NMR Dimethyl sulfoxide Sodium chloride foetal bovine serum polydispersity index Stromal cell-derived factor-1α Collapse temperature Phosphate-buffered saline Dulbecco’s modified eagle’s medium SEM ICH Scanning electron microscopy Transmission electron microscopy atomic force microscopy Polymeric nanoparticles Lipid nanocapsules Isoelectric point C-X-C chemokine receptor type 4 Hydroxypropyl-β-cyclodextrin weight-average molecular weight number-average molecular weight polyethylene glycol polyvinyl alcohol PEG Polystyrene poloxamer 188 Size exclusion chromatography International Conference on Harmonization Protein encapsulation Glioblastoma

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Life Sciences Biochemistry, Genetics and Molecular Biology Biotechnology

Development of a non-toxic and non-denaturing formulation process for encapsulation of SDF-1Î± into PLGA/PEG-PLGA nanoparticles to achieve sustained release

Authors

Muhammad Haji Mansor, Mathie Najberg, Aurélien Contini, Carmen Alvarez-Lorenzo, Emmanuel Garcion, Christine JérÃ´me, Frank Boury,