Oral bioavailability enhancement of Î²-lapachone, a poorly soluble fast crystallizer, by cocrystal, amorphous solid dispersion, and crystalline solid dispersion

Article ID	Journal	Published Year	Pages	File Type
8412144	European Journal of Pharmaceutics and Biopharmaceutics	2018	30 Pages	PDF

Keywords

DSC HPMC-AS scXRD HP-β-CD P188 CSD LPC Liquid-assisted grinding POM PVP HPMC MCC β-Lapachone Lag Microcrystalline cellulose Bioavailability SEM scanning electron microscope Polarized optical microscopy ASD hydroxypropyl-beta-cyclodextrin Hydroxypropylmethylcellulose Hydroxypropylmethylcellulose acetate succinate Wide-angle X-ray diffraction single crystal X-ray diffraction Amorphous solid dispersion polyvinylpyrrolidone Differential scanning calorimetry croscarmellose sodium high performance liquid chromatography HPLC Cocrystal

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biotechnology

Oral bioavailability enhancement of Î²-lapachone, a poorly soluble fast crystallizer, by cocrystal, amorphous solid dispersion, and crystalline solid dispersion

Authors

Chengyu Liu, Zhengsheng Liu, Yuejie Chen, Zhen Chen, Huijun Chen, Yipshu Pui, Feng Qian,