Physical stability of API/polymer-blend amorphous solid dispersions

Article ID	Journal	Published Year	Pages	File Type
8412190	European Journal of Pharmaceutics and Biopharmaceutics	2018	11 Pages	PDF

Keywords

SEG ARD HPMCAS VLE APAP PVP PC-SAFT Disp RES PXRD NAP temperature (K)API Calcd HPMC DSC Experimental Association Acetaminophen Residual Vapor Segment Boltzmann constant Perturbed-chain statistical associating fluid theory Vapor-liquid equilibrium Solid-liquid equilibrium Physical stability solid-liquid Relative humidity Phase behavior intercept international council for harmonisation of technical requirements for pharmaceuticals for human use Slope Activity coefficient Excipients Solid phase Liquid phase SLE calculated Thermodynamic model ICH Active Pharmaceutical Ingredient average relative deviation Naproxen ASD Hydroxypropyl methylcellulose Powder X-Ray Diffraction Dispersion Amorphous solid dispersion Polymer blends Differential scanning calorimetry Mole fraction

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biotechnology

Physical stability of API/polymer-blend amorphous solid dispersions

Authors

Kristin Lehmkemper, Samuel O. Kyeremateng, Mareike Bartels, Matthias Degenhardt, Gabriele Sadowski,