Implementation of transmission NIR as a PAT tool for monitoring drug transformation during HME processing

Article ID	Journal	Published Year	Pages	File Type
8412898	European Journal of Pharmaceutics and Biopharmaceutics	2015	11 Pages	PDF

Keywords

DSC FDA XRPD QbD NIR API HME PCA Transmission ind Indomethacin Hot-melt extrusion Reflectance Principal component analysis Process analytical technology Food and Drug Administration Sol Soluplus Active pharmaceutical ingredients Near Infrared spectroscopy In-line monitoring Raman mapping pat X-ray powder diffraction Differential scanning calorimetry Quality by design

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biotechnology

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Implementation of transmission NIR as a PAT tool for monitoring drug transformation during HME processing

Authors

Muhammad T. Islam, Nikolaos Scoutaris, Mohammed Maniruzzaman, Hiren G. Moradiya, Sheelagh A. Halsey, Michael S.A. Bradley, Babur Z. Chowdhry, Martin J. Snowden, Dennis Douroumis,