Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8414619 | European Journal of Pharmaceutics and Biopharmaceutics | 2013 | 7 Pages |
Abstract
In asthma, the airways undergo many structural and functional changes caused by environmental factors and genetic predisposition including a damaged epithelium, mucus hyper-secretion, thickening of the basement membrane, fibroblast and smooth muscle layer, angiogenesis and increased inflammation. To understand the underlying disease mechanisms, there is a need for a range of in vitro models that incorporate genetic and epigenetic features of the disease through use of asthma-derived cells.
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Authors
Cornelia Blume, Donna E. Davies,