Biorelevant in vitro dissolution testing of products containing micronized or nanosized fenofibrate with a view to predicting plasma profiles

The graphical abstract shows: the difference in dissolution profile when using an appropriate and an inappropriate filter pore size (above), the resulting plasma profile if bioavailability is determined by dissolution rate for both the nanosized and microsized formulation (middle), the resulting plasma profile if bioavailability is limited by absorption for the nanosized formulation.