Swelling kinetics of spray-dried chitosan acetate assessed by magnetic resonance imaging and their relation to drug release kinetics of chitosan matrix tablets

A high potential technique, magnetic resonance imaging (MRI), was used to monitor in situ swelling behavior of spray dried chitosan acetate, CSA, in various media i.e, 0.1 N HCl, pH 6.8 and 5.0 Tris HCl buffers. The linear relationship between percentage of swelling and drug release from CSA matrix tablets exhibited the important role of the swelling behavior of the polymer on controlling the drug release.