Clinical evaluation of the BioPlex 2200 Celiac IgA and IgG Kits - A novel multiplex screen incorporating an integral check for IgA deficiency

Use of the BioPlex® 2200 Celiac IgA and Celiac IgG kits in a standard protocol gave excellent sensitivity and specificity with highly effective detection of IgAD, no false positive IgAD flags and little evidence of interference from high IgA levels. The ability to detect IgAD without pre-screening with a separate IgA assay should have a significant beneficial impact on laboratory workflow by identifying those patients requiring IgG based testing and IgA measurement to confirm IgAD.