Inflammatory protein profiling of pancreatic cyst fluid using EUS-FNA in tandem with cytokine microarray differentiates between branch duct IPMN and inflammatory cysts

► EUS-FNA-sampled pancreatic cystic neoplasms are analyzed using a cytokine microarray. ► Seven IMPs were detected in BD-IPMN, but not in inflammatory cysts. ► Eleven IMPs were detected in inflammatory cysts, but not in BD-IMPNs. ► GM-CSF and HGF in pancreatic cyst fluid distinguishes BD-IPMN and inflammatory cysts. ► Coupling microarrays to EUS-FNA is a major step in understanding pancreatic disease.