| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8418753 | Journal of Immunological Methods | 2012 | 13 Pages |
Abstract
⺠AGR2 is a pro-oncogenic protein implicated in Tamoxifen resistance and metastasis. ⺠AGR3 is the conserved AGR2 orthologue whose role in cancer is unclear. ⺠Monoclonal antibodies were generated towards AGR3 to evaluate its expression in vivo. ⺠AGR3 was expressed in four ovarian cancer subtypes and was uncoupled from AGR2. ⺠AGR3 mediates cisplatin resistance in vivo and presents a novel drug target.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biotechnology
Authors
Terry A. Gray, Nicola J. MacLaine, Caroline O. Michie, Pavla Bouchalova, Euan Murray, Jacqueline Howie, Roman Hrstka, Magdalena M. Maslon, Rudolf Nenutil, Borek Vojtesek, Simon Langdon, Larry Hayward, Charlie Gourley, Ted R. Hupp,