| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8418991 | Journal of Immunological Methods | 2012 | 11 Pages |
Abstract
This study validated CD80 as the most robust phenotypic marker for human MΦIFN-γ, whereas CD200R was upregulated and CD14 was specifically downregulated on MΦIL-4. CD163 and CD16 were found to be specific markers for MΦIL-10. The GM-CSF/M-CSF differentiation model showed only a partial phenotypic similarity with the IFN-γ/IL-4/IL-10 induced polarization.
Keywords
JnkFizz-1PD-L2Jun N-terminal kinaseAPCERKGAPDHMAPKinflammationTAMTumor associated macrophageATMantigen presenting cellFlow cytometryMacrophage polarizationAdipose tissue macrophagecell surface moleculesPhenotypic markersmitogen-activated protein kinaseextracellular signal-regulated kinaseglyceraldehyde 3-phosphate dehydrogenase
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Authors
C.A. Ambarus, S. Krausz, M. van Eijk, J. Hamann, T.R.D.J. Radstake, K.A. Reedquist, P.P. Tak, D.L.P. Baeten,