| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8419152 | Journal of Immunological Methods | 2011 | 13 Pages |
Abstract
âºMAp19 and MASP-2 were both mainly expressed in hepatocytes. âºThe MAp19 concentration in serum was 217 ng/ml, 11 nM, comparable to that of MASP-2. âºIn serum all MASP-2, but only a minor fraction of MAp19, was associated with PRMs. âºHigh levels of MAp19 were found in urine, where MASP-2 was absent. âºMAp19 cannot compete with MASP-2 for binding to MBL, nor inhibit complement activation.
Keywords
PRMo.n.HIgGTRIFMAMAp19SMAPMASP-2MASPC1-INHMBSMBLPPDNHSDVSHRPBCGKLHPAMPPABBacillus Calmette-GuérinC1 inhibitorPolyclonal antibodypathogen-associated molecular patternTime-resolved immunofluorometric assayRoom temperatureDivinylsulfonenormal human serumMannan-binding lectinComplementlectin pathwaypurified protein derivativemapHorseradish peroxidaseMBL-associated serine proteasekeyhole limpet hemocyaninovernight
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Authors
Søren E. Degn, Steffen Thiel, Ole Nielsen, Annette G. Hansen, Rudi Steffensen, Jens C. Jensenius,