| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8419377 | Journal of Immunological Methods | 2011 | 9 Pages |
Abstract
⺠Therapeutic monoclonal antibodies (mAbs) can cause clinical infusion reactions. ⺠Two methods for predicting the risk of occurrence of such reactions are evaluated. ⺠Largest cytokine responses were to mAbs associated with clinical infusion reactions.
Keywords
IL-6TNFTGN1412PhytohaemagglutininTMBPBMCsmAbsPHA3,3′,5,5′-tetramethylbenzidineTherapeutic monoclonal antibodiesinterleukin-6Enzyme-linked immunosorbent assayELISAtumour necrosis factor-αperipheral blood mononuclear cellsEndothelial cellsCytokine Release SyndromeVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)Monoclonal antibodies
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biotechnology
Authors
Lucy Findlay, David Eastwood, Christina Ball, C. Jane Robinson, Chris Bird, Meenu Wadhwa, Susan J. Thorpe, Robin Thorpe, Richard Stebbings, Stephen Poole,