Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8419377 | Journal of Immunological Methods | 2011 | 9 Pages |
Abstract
⺠Therapeutic monoclonal antibodies (mAbs) can cause clinical infusion reactions. ⺠Two methods for predicting the risk of occurrence of such reactions are evaluated. ⺠Largest cytokine responses were to mAbs associated with clinical infusion reactions.
Keywords
IL-6TNFTGN1412PhytohaemagglutininTMBPBMCsmAbsPHA3,3′,5,5′-tetramethylbenzidineTherapeutic monoclonal antibodiesinterleukin-6Enzyme-linked immunosorbent assayELISAtumour necrosis factor-αperipheral blood mononuclear cellsEndothelial cellsCytokine Release SyndromeVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)Monoclonal antibodies
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Authors
Lucy Findlay, David Eastwood, Christina Ball, C. Jane Robinson, Chris Bird, Meenu Wadhwa, Susan J. Thorpe, Robin Thorpe, Richard Stebbings, Stephen Poole,