Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8420080 | Journal of Immunological Methods | 2008 | 14 Pages |
Abstract
The CD8+ T cell response is important in the control of many viral and other infections. There have been many studies aimed at better understanding the influence of T cell receptor diversity on immune responses and the evolution of the T cell receptor repertoire over time and through the various stages of immune responses to infection. In recent years, there has been an increase in both the number of studies using T cell receptor data and the volume of T cell receptor data generated per study. Appropriate analytical tools are required to analyse this data. We present a robust approach to assessing the similarity between samples of the T cell receptor repertoire, which we demonstrate on published data of subsets of the influenza A virus DbNP366- and DbPA224-specific CD8+ T cell responses in mice sorted on the expression of CD62L, which is a marker distinguishing central and effector memory cells.
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Authors
Vanessa Venturi, Katherine Kedzierska, Mark M. Tanaka, Stephen J. Turner, Peter C. Doherty, Miles P. Davenport,