Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8422695 | Microbiological Research | 2018 | 4 Pages |
Abstract
The irrational use of antibiotics in agriculture and in the medical field has led to a variety of pathogenic microorganisms that produce drug resistance and even multidrug resistance. B-lactam is one of the most widely used antibiotics to treat infectious diseases. Resistance to β-lactam resistance can be primarily due to the presence β-lactamase, mutation of β-lactam targets and overexpression of efflux pumps. Two-component regulatory systems are composed of histidine kinase and response regulator that regulate gene expression under different environmental conditions. In this review, we summarized the mechanisms by which β-lactam resistance is developed and the role of the two-component regulatory system in β-lactam resistance.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biotechnology
Authors
Lingzhi Li, Haojie Ge, Dan Gu, Hongmei Meng, Yang Li, Mengdie Jia, Chengkun Zheng, Xiaohui Zhou,