Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8425939 | Synthetic and Systems Biotechnology | 2017 | 8 Pages |
Abstract
Microbial production of plant-derived natural products by engineered microorganisms has achieved great success thanks to large extend to metabolic engineering and synthetic biology. Anthocyanins, the water-soluble colored pigments found in terrestrial plants that are responsible for the red, blue and purple coloration of many flowers and fruits, are extensively used in food and cosmetics industry; however, their current supply heavily relies on complex extraction from plant-based materials. A promising alternative is their sustainable production in metabolically engineered microbes. Here, we review the recent progress on anthocyanin biosynthesis in engineered bacteria, with a special focus on the systematic engineering modifications such as selection and engineering of biosynthetic enzymes, engineering of transportation, regulation of UDP-glucose supply, as well as process optimization. These promising engineering strategies will facilitate successful microbial production of anthocyanins in industry in the near future.
Keywords
4CLflavonoid 3-O-glucosyltransferaseDFRFGTF3HCHSCHIDSSC4-Coumaroyl-CoA ligaseF3′5′HF3′Hflavonoid 3′-hydroxylaseAnthocyaninUltravioletMicrobial productiondihydroflavonol 4-reductaseANSDye-sensitized solar cellanthocyanidin synthasechalcone synthaseflavanone 3-hydroxylaseEnzyme engineeringMetabolic engineeringchalcone isomerase
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Authors
Jian Zha, Mattheos A.G. Koffas,