Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8429286 | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | 2018 | 37 Pages |
Abstract
p53 is an important tumour suppressor gene, with loss of p53 contributing to the development of most human cancers. However, the activation of p53 in response to stress signals underpins a role for p53 in diverse aspects of health and disease. Activities of p53 that regulate metabolism can play a role in maintaining homeostasis and protecting cells from damage - so preventing disease development. By contrast, either loss or over-activation of p53 can contribute to numerous metabolic pathologies, including aging, obesity and diabetes.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Christiaan F. Labuschagne, Fabio Zani, Karen H. Vousden,