Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8429325 | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | 2018 | 52 Pages |
Abstract
De-regulated cellular energetics is an emerging hallmark of cancer with alterations to glycolysis, oxidative phosphorylation, the pentose phosphate pathway, lipid oxidation and synthesis and amino acid metabolism. Understanding and targeting of metabolic reprogramming in cancers may yield new treatment options, but metabolic heterogeneity and plasticity complicate this strategy. One highly heterogeneous cancer for which current treatments ultimately fail is the deadly brain tumor glioblastoma. Therapeutic resistance, within glioblastoma and other solid tumors, is thought to be linked to subsets of tumor initiating cells, also known as cancer stem cells. Recent profiling of glioblastoma and brain tumor initiating cells reveals changes in metabolism, as compiled here, that may be more broadly applicable. We will summarize the profound role for metabolism in tumor progression and therapeutic resistance and discuss current approaches to target glioma metabolism to improve standard of care.
Keywords
AsnSCpt1aCCOMGMTPEPGBMECARGLUT3AMPKNF1Drp1IDHPDGFRPDK1GLUT1OCRPDHTMZHIF1αAldolase CHIF2αALDOAPKM2PDP1FABP7LXRsCPT1c2-HGNF-κBG6PDPPPFDG-PETOXPHOSALDH1EGFRHMGCRLDLRDCA2-DG2-Hydroxyglutarate3-hydroxy-3-methylglutaryl-CoA reductase5′ AMP-activated protein kinaseO-6-Methylguanine-DNA MethyltransferaseROSasparagine synthetasealdehyde dehydrogenaseAldolase Afatty acid synthaseglucose transporter 3Isocitrate dehydrogenaseTemozolomidetumor initiating cellNovel therapeuticsDichloroacetateelectron transport chaincancer stem cellcytochrome c oxidasenuclear factor kappa betaFasnphosphoenolpyruvateOxidative phosphorylationlactate dehydrogenaseLDHMetabolismpentose phosphate pathwayTherapeutic resistanceOxygen consumption rateextracellular acidification rateNeurofibrominhexokinaseETcdynamin related protein 1platelet derived growth factor receptorpyruvate dehydrogenasePyruvate dehydrogenase kinase 1TCA cycletricarboxylic acid cyclecarnitine palmitoyltransferase 1aglucose transporter 1glucose-6-phosphate dehydrogenaseGlioblastomaReactive oxygen speciesEpidermal growth factor receptorlow density lipoprotein receptorLiver X receptors
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Authors
Catherine J. Libby, Anh Nhat Tran, Sarah E. Scott, Corinne Griguer, Anita B. Hjelmeland,