Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8429424 | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | 2014 | 15 Pages |
Abstract
The NFAT signaling pathway regulates various aspects of cellular functions; NFAT acts as a calcium sensor, integrating calcium signaling with other pathways involved in development and growth, immune response, and inflammatory response. The NFAT family of transcription factors regulates diverse cellular functions such as cell survival, proliferation, migration, invasion, and angiogenesis. The NFAT isoforms are constitutively activated and overexpressed in several cancer types wherein they transactivate downstream targets that play important roles in cancer development and progression. Though the NFAT family has been conclusively proved to be pivotal in cancer progression, the different isoforms play distinct roles in different cellular contexts. In this review, our discussion is focused on the mechanisms that drive the activation of various NFAT isoforms in cancer. Additionally, we analyze the potential of NFAT as a valid target for cancer prevention and therapy.
Keywords
ECMDCANF-κBPI3KnESFOXP3JnkHDACsMmpsNFATCNATCrERKPMLSRRPGE2pKaADPGPCRsIP3IL-2BMP4AICDIP3Rangiopoietin-2GSK3βGM-CSFPLCγPARPNLSCK1LPAEWSR1RHDTonEBPCNBVEGFRAP1CDK4CSF1DSCR1PIP2NHDTEM8Foxc2forkhead box C2PROX1SUMO1Colony-stimulating factor-1Calcineurin BAKAP79prospero homeobox 1c-Jun KinaseECsG-protein coupled receptorsinositol-1,4,5-triphosphateMAPKsMitogen activated protein kinasesROSRTKsAng-2Adenosine di-phosphatelysophosphatidic acidCSAInterleukin-2TADNuclear localization sequencesforkhead box P3transactivation domainrel-homology domaindiacylglycerolDYRKDAGCAMEndothelial cellsSOCcyclosporin ACyclin Dependent Kinase 4nuclear export signalendoplasmic reticulumNuclear Factor of Activated T Cellsgranulocyte-macrophage colony-stimulating factorTranscription factorsFas LigandFasLVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)nuclear factor-κBphosphatidylinositol 4,5-bisphosphatephospholipase CγPromyelocytic leukemiaMatrix metalloproteinasesactivation-induced cell deathSmall molecule inhibitorSmall molecule inhibitorsDrug targethistone deacetylasesactivator protein 1bone morphogenetic protein 4protein kinase AProstaglandin E2poly-ADP-ribose polymeraseCdScasein kinase 1CalmodulinStore-operated calcium channelCalcineurin AReactive oxygen speciesIP3 receptorVEGF receptorreceptor tyrosine kinasesT-cell receptors
Related Topics
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Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Jiang-Jiang Qin, Subhasree Nag, Wei Wang, Jianwei Zhou, Wei-Dong Zhang, Hui Wang, Ruiwen Zhang,