Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8429462 | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | 2012 | 19 Pages |
Abstract
In the UK, four in ten people will develop some form of cancer during their lifetime, with an individual's relative risk depending on many factors, including age, lifestyle and genetic make-up. Much research has gone into identifying the genes that are mutated in tumorigenesis with the over-whelming majority of genetically-modified (GM) mice in cancer research showing accelerated tumorigenesis or recapitulating key aspects of the tumorigenic process. Yet if six out of ten people will not develop some form of cancer during their lifetime, together with the fact that some cancer patients experience spontaneous regression/remission, it suggests there are ways of 'resisting' cancer. Indeed, there are wildtype, spontaneously-arising mutants and GM mice that show some form of 'resistance' to cancer. Identification of mice with increased resistance to cancer is a novel aspect of cancer research that is important in terms of providing both chemopreventative and therapeutic options. In this review we describe the different mouse lines that display a 'cancer resistance' phenotype and discuss the molecular basis of their resistance.
Keywords
IKK12-O-tetradecanoylphorbol-13-acetateMCP-1CCl4RBDDMBAAPCDenMNNGIκBazoxymethaneIFN-γMNUSCIDNF-κBTGFMMTVPLA2TNFRPAR17,12-dimethylbenz[α]anthracenePI3PR-SmadsIkappaBReceptor-activated SmadsN-Nitroso-N-methylureaTNFCTLA-4UVBMEFDSScentiMorgantPASACPI3KSCCDSBCOXAOMNOSNERIκB kinaseN-methyl-N′-nitro-N-nitrosoguanidinetelomerase RNAAdenocarcinomaT antigencytotoxic T-lymphocyte antigen 4antigen-presenting cellsphospholipase A2Polyunsaturated fatty acidsPUFAultraviolet BGenetically modifiedinterferon-gammainterleukinMajor histocompatibilitytransforming growth factorTERTTelomerase reverse transcriptaseTAG یا triacylglycerols NMRnucleotide excision repairTumorigenesisRas binding domaindiethylnitrosamineRASSFCancerTh cellDendritic cellsT helper celldextran sodium sulfatecyclo-oxygenasetumor necrosis factornuclear factor kappa Bphosphatidylinositol 3-phosphatephosphoinositide 3-kinaseMoMMHCResistanceUTR یا untranslated regions untranslated regionMouseNaked mole-ratmouse embryonic fibroblastsmegabaseNitric oxidenitric oxide synthaseMouse mammary tumor virusmonocyte chemoattractant protein-1Squamous cell carcinomaSmall cell carcinomaCarbon tetrachloridesevere combined immunodeficiencyUlcerative colitistumor necrosis factor receptor
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Authors
Louise van der Weyden, David J. Adams,