Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8429571 | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | 2009 | 22 Pages |
Abstract
The elucidation of the human and mouse genome sequence and developments in high-throughput genome analysis, and in computational tools, have made it possible to profile entire cancer genomes. In parallel with these advances mouse models of cancer have evolved into a powerful tool for cancer gene discovery. Here we discuss the approaches that may be used for cancer gene identification in both human and mouse and discuss how a cross-species 'oncogenomics' approach to cancer gene discovery represents a powerful strategy for finding genes that drive tumourigenesis.
Keywords
Related Topics
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Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Jenny Mattison, Louise van der Weyden, Tim Hubbard, David J. Adams,