| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8429580 | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | 2009 | 7 Pages |
Abstract
In this paper we will review the molecular mechanisms by which estrogens are involved in cancer development, with a special focus in Lynch syndrome related neoplasia. Further, we discuss the role estrogens might have on cell proliferation and apoptosis, how estrogens metabolites can induce DNA damage and we discuss a possible connection between estrogens and changes in DNA (hypo- and hyper) methylation. In this review we will also address the protective effect that high levels of estrogens have in MMR related neoplasias.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Ana Monteiro Ferreira, Helga Westers, André Albergaria, Raquel Seruca, Robert M.W. Hofstra,