Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8429881 | Biology of Blood and Marrow Transplantation | 2018 | 15 Pages |
Abstract
Pretransplant gut colonization with intrinsically vancomycin-resistant enterococci (iVRE) (Enterococcus gallinarum and Enterococcus casseliflavus) is uncommon and with unknown clinical impact. In a matched-pairs analysis of patients with versus without iVRE colonization (nâ=â18 in each group), we demonstrated significantly higher 2-year overall survival (86% [95% confidence interval, 52% to 96%] versus 35% [95% confidence interval, 8% to 65]; Pâ<.01) and lower nonrelapse mortality (Pâ<.01) among colonized patients. Putative metabolomes differentiated iVRE from E. faecalis/faecium and may contribute to a healthier gut microbiome in iVRE-colonized patients.
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Authors
Armin Rashidi, Maryam Ebadi, Robin R. Shields-Cutler, Todd E. DeFor, Gabriel A. Al-Ghalith, Patricia Ferrieri, Jo-Anne H. Young, Gary M. Dunny, Dan Knights, Daniel J. Weisdorf,