Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8430692 | Biology of Blood and Marrow Transplantation | 2017 | 20 Pages |
Abstract
Minor histocompatibility antigen (miHA) mismatches have been related to graft-versus-host disease (GVHD) after allogeneic stem cell transplantation, but this association remains controversial due to the lack of consistency in the results obtained by different groups. The CTLA-4 genotype of the donor has been reported to be relevant in the appearance of acute GVHD. We explored the effect of the donor's CTLA-4 genotype in the incidence of acute GVHD associated with HA-1, HA-8, or H-Y miHA mismatches in a large cohort of 1295 patients receiving an allogeneic transplant from an HLA-identical sibling donor. The incidence of acute GVHD was higher if the donor and recipient were mismatched for HA-1, HA-8, or H-Y, but only when the donor had the CTLA-4 rs231775 AA genotype (hazard ratio [HR], 2.18; 95% confidence interval [CI], 1.27 to 3.75; Pâ=â.005; HR, 2.11, 95% CI, 1.06 to 4.18; Pâ=â.033; and HR, 1.50; 95% CI, 1.05 to 2.15; Pâ=â.025, respectively). In contrast, this increased risk of developing acute GVHD was not found when the donor presented the CTLA-4 rs231775 AG or GG genotypes. We conclude that the immune response to specific miHA mismatches is modulated by the CTLA-4 genotype of the donor.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
David Gallardo, Anna Bosch-Vizcaya, RocÃo RodrÃguez-Romanos, Nazly Santos, Ismael Buño, Rafael de la Cámara, Salut Brunet, Antonio Jiménez-Velasco, Marcos González, Jose B. Nieto, Carolina MartÃnez-Laperche, Carlos Vallejo, Christelle Ferrá,