Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8431791 | Biology of Blood and Marrow Transplantation | 2008 | 6 Pages |
Abstract
Elevated serum ferritin is associated with reduced survival following allogeneic transplantation and an increased risk of toxic and infectious complications after autologous hematopoietic stem cell transplantation (ASCT). We studied 315 patients who underwent ASCT for Hodgkin (HL) or non-Hodgkin lymphoma (NHL) at our institution in whom pretransplantation ferritin was available to determine its association with survival. On multivariate analysis, a pretransplantation ferritin >685 ng/mL was associated with significantly lower overall (OS; P = .002) and relapse-free survival (RFS; P = .021). Ferritin >685 ng/mL was associated with a higher incidence of relapse (P = .005) and relapse mortality (P < .001), but not of nonrelapse mortality (NRM; P = .23). Similar results were seen when pretransplantation ferritin was analyzed as a continuous variable and by quartiles. Our results indicate the need for studies designed to correlate an elevated ferritin with iron overload and to analyze the benefit of strategies to reduce the extent of iron overload.
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Authors
Anuj Mahindra, Brian Bolwell, Ronald Sobecks, Lisa Rybicki, Brad Pohlman, Robert Dean, Steve Andresen, John Sweetenham, Matt Kalaycio, Edward Copelan,