Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8434235 | Cancer Letters | 2018 | 31 Pages |
Abstract
Immunometabolism is an emerging field that focuses on the role of cellular metabolism in the regulation of immune cells. Recent studies have revealed an intensive link between the metabolic state and the functions of immune cells. MicroRNAs (miRNAs) are small non-coding, single-stranded RNAs generally consisting of 18-25 nucleotides that exert crucial roles in regulating gene expression at the posttranscriptional level. Although the role of miRNAs in immune regulation has long been recognized, their roles in immunometabolism have not yet been well established. Over the past decade, increasing studies have proven that miRNAs are intensively involved in the metabolic control of immune cells including macrophages, T cells, B cells and dendritic cells. In this review, we highlight recent emerging findings in the miRNA-mediated metabolic control of immune cells.
Keywords
PPPPEPGLUT1TregsANGPTL4TCrmTORLPLTCAScd2NKTα-KGTFHHIF1αPI3KAMPKAMP-activated protein kinasenon-coding RNAsTLRsAdenosine TriphosphateATPalpha-ketoglutarateangiopoietin-like 4Fatty acid oxidationImmunometabolismMetabolic reprogrammingBregsnatural killer T cellFollicular helper T cellsregulatory B cellsT cellsRegulatory T cellshypoxia-inducible factor 1-αFAOphosphatidylinositol 3 kinasephosphoenolpyruvateLipoprotein lipaseMacrophagespentose phosphate pathwaymammalian target of rapamycintricarboxylic acid cycleglucose transporter 1T-cell receptorToll-like receptors
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Authors
Qiuming Yao, Zhenyu Song, Bin Wang, Jin-an Zhang,