| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8434255 | Cancer Letters | 2018 | 37 Pages |
Abstract
A schematic representation of the potential mode of interaction between cancer cells and fibroblasts upon extracellular ATP stimulation. Extracellular ATP in the tumor microenvironment acts not only on breast cancer cells but also on fibroblasts. â ATP promotes cancer cell pseudopodia formation and migration through upregulation of intracellular S100A4, and â¡enhances the ability of cancer cells to transform fibroblasts into cancer-associated fibroblasts (CAF)-like cells (also termed activated fibroblasts), which in turn â¢secret S100A4 to act on cancer cells and exacerbate tumor migration.241
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Authors
Ying Liu, Yue-Hang Geng, Hui Yang, Han Yang, Yan-Ting Zhou, Hong-Quan Zhang, Xin-Xia Tian, Wei-Gang Fang,