Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8434279 | Cancer Letters | 2018 | 21 Pages |
Abstract
Immune checkpoint proteins (ICPs) are regulators of immune system. The ICP dysregulation silences the host immune response to cancer-specific antigens, contributing to the occurrence and progress of various cancers. MiRNAs are regulatory molecules and function in mRNA silencing and post-transcriptional regulation of gene expression. MiRNAs that modulate the immunity via ICPs have received increasing attention. Many studies have shown that the expressions of ICPs are directly or indirectly repressed by miRNAs in multiple types of cancers. MiRNAs are also subject to regulation by ICPs. In this review, recent studies of the relationship between miRNAs and ICPs (including the PD-1, PD-L1, CTLA-4, ICOS, B7-1, B7-2, B7-H2, B7-H3, CD27, CD70, CD40, and CD40L) in cancer immune escape are comprehensively discussed, which provide critical detailed mechanistic insights into the functions of the miRNA-ICP axes and their effects on immune escape, and will be beneficial for the potential applications of immune checkpoint therapy and miRNA-based guidance for personalized medicine as well as for predicting the prognosis.
Keywords
B and T lymphocyte attenuatorDCsTLRDnmt1BTLAMPMCLLMDSCsTNFRIFNGRLNsTFHTregsTRAFCIKAIHAICOSIRF-1DNA methyltransferase 1BMDMsCKS1BICPSTNFAMLIFN-γTCrAPCsmiRNAsHClPD-1MLAPBMCJanus kinase3′UTRHCCpDCsSp1Stat1Argonaute 2Antigen presenting cellsAgo2interferon-γTumor-infiltrating lymphocytestumor necrosis factor αToll-like receptorTILSCNSNon-small-cell lung cancerNSCLCperipheral blood mononuclear cellsDendritic cellsMyeloid-derived suppressor cellsplasmacytoid dendritic cellsRegulatory T cellscentral nervous systemInterferon regulatory factor 1TNF receptor associated factortumor necrosis factorTNF-αacute myeloid leukemiahairy cell leukemiaChronic lymphocytic leukemiaSLEsignal transducer and activator of transcription 1germinal centreMalignant pleural mesotheliomaSingle nucleotide polymorphismSNPJAKHepatocellular carcinomaAutoimmune hemolytic anemiaT follicular helperlymph nodesIFN-γ receptorT cell receptor
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Authors
Qin Yang, Wenjie Cao, Zi Wang, Bin Zhang, Jing Liu,