Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8434422 | Cancer Letters | 2018 | 65 Pages |
Abstract
As the most well-known circular RNA, ciRS-7 (also termed CDR1as) has been reported to act as a miR-7 sponge, resulting in reduced miR-7 activity and increased miR-7-targeted transcripts. Here, we showed that ciRS-7 is up-regulated in esophageal squamous cell carcinoma (ESCC), and is associated with the poor clinicopathological parameters of ESCC patients. Moreover, over-expression of ciRS-7 increased the proliferation, migration and invasion of ESCC cells. Mechanistic studies revealed that ciRS-7 contains nineteen miR-876-5p binding sites and acts as a miR-876-5p sponge. Over-expression of ciRS-7 resulted in the reduced tumor-repressive function of miR-876-5p on its downstream target MAGE-A family. In animal experiments, enforced ciRS-7 increased ESCC tumor growth and metastasis through targeting miR-876-5p/MAGE-A family axis. Collectively, our study provided novel evidence that ciRS-7 accelerates ESCC progression by acting as a miR-876-5p sponge to enhance MAGE-A family expression.
Keywords
Related Topics
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Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Meixiang Sang, Lingjiao Meng, Yang Sang, Shina Liu, Pingan Ding, Yingchao Ju, Fei Liu, Lina Gu, Yishui Lian, Juan Li, Yunyan Wu, Xiaochong Zhang, Baoen Shan,