| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8435676 | Cancer Letters | 2014 | 9 Pages |
Abstract
(GAD65/67) and GABAB receptor are expressed in 4T1 mouse breast cancer cells, MCF-7 human breast cancer cells and human breast cancer tissue. Baclofen, a GABABR agonist, significantly promoted 4T1 cells invasion and migration in vitro and metastasis in vivo, an event that was attenuated by GABABR antagonist CGP55845. Baclofen-induced breast cancer metastasis was mediated by ERK1/2 pathway.
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Cancer Research
Authors
Depu Zhang, Xiaowei Li, Ziming Yao, Chuanfei Wei, Nannan Ning, Jingxin Li,