Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8435699 | Cancer Letters | 2013 | 9 Pages |
Abstract
Advances in cancer genomics have been propelled by the steady evolution of molecular profiling technologies. Over the past decade, high-throughput sequencing technologies have matured to the point necessary to support disease-specific shotgun sequencing. This has compelled whole-genome sequencing studies across a broad panel of malignancies. The emergence of high-throughput sequencing technologies has inspired new chemical and computational techniques enabling interrogation of cancer-specific genomic and transcriptomic variants, previously unannotated genes, and chromatin structure. Finally, recent progress in single-cell sequencing holds great promise for studies interrogating the consequences of tumor evolution in cancers presenting with genomic heterogeneity.
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Authors
Lalit R. Patel, Matti Nykter, Kexin Chen, Wei Zhang,