| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8435732 | Cancer Letters | 2013 | 11 Pages |
Abstract
⺠SnoRNAs and tRNAs are specifically processed to different, functional types of smaller RNAs referred to as sdRNAs and tRFs. ⺠The expression of many snoRNAs, tRNAs, and derived from them smaller RNAs is altered in human disease and cancer. ⺠SdRNAs and tRFs share components of the molecular pathways of RNAi and may function in gene regulation or stress signaling. ⺠SnoRNAs, tRNAs, and derived from them smaller RNAs are potential oncogenes or tumor suppressor genes. ⺠SdRNAs and tRFs may provide new perspectives for the development of novel biomarkers and therapeutic strategies in cancer.
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Authors
Elena S. Martens-Uzunova, Michael Olvedy, Guido Jenster,